The world is experiencing an era of digital transformation resulting from the industry 4.0 or fourth industrial revolution. In this period, technology has played an increasingly strategic role in the performance of organizations. These technological advances have revolutionized the decision-making process in the management and operation of supply chains. In this context, this dissertation presents a methodology to support decision-making in inventory management, which combines multi-criteria decision-making (MCDM) and machine learning (ML). At first, there is a systematic literature review in order to analyze how these two approaches are applied in inventory management. The results are complemented with a scoping review that includes the demand forecasting. A case study is then applied to a freight transport railway. Initially, the MCDM combined Fuzzy AHP Vikor method is applied to rank stock keeping units (SKUs) in degrees of criticality. The next step is the application of the ML combined GA-ANN method, artificial neural network with genetic algorithm, for the purpose of demand forecasting in a pilot with some of the most critical items. The final step is to structure a management dashboard, integrating the results of the previous steps. Among the results achieved from the proposed model, there is a considerable improvement in the performance of the demand forecasting for the selected SKUs. In addition, the integration between approaches and implementation in a management dashboard allowed the development of a semiautomatic model for decision-making in inventory management.