In the present work the synthesis and characterization of solid state zinc and cadmium complexes with sulfured amino acids were performed. Binary and ternary complexes, involving glycine, aspartic acid, methionine, cysteine and glutathione tripeptide were synthetized. These compounds form several proteins that act in the central nervous system. Although studies on the formation of complexes between these metals and amino acids in solution, were realized it is a relevant and interesting topic the fact that in several neuro-degenerative illness occur the precipitation of solid agglomerates from proteins. This shows the necessity of study these systems in the solid state. Thus, in the present work, different routes of synthesis were developed in similar conditions to the biological medium. Simple models were synthesized and characterized by Infrared spectroscopy, Raman spectroscopy, Thermogravimetric analysis, Elemental analysis and Atomic absorption spectrometry. These complexes allow the comprehension of the complex molecules which form these systems. A compound with cysteine was chosen to perform a detailed spectroscopic study using quantum mechanical calculation which permitted identification of the the infrared and Raman spectra bands, M-S and M-N which are very difficult to characterize. The conclusion of this work showed that the big affinity of these metals (zinc and cadmium) for sulfur allowed the synthesis in acid medium. It was observed a reduction in the tendency of precipitation when passing binary from binary to ternary compounds and then to glutathione. Tripeptides like glutathione facilitated the formation of stable colloidal solutions, and the formation of solid phases only occurred after a considerable period of time, so, an increase in the zeta potential allows the formation of a solid phase in few hours.