$$\newcommand{\bra}[1]{\left<#1\right|}\newcommand{\ket}[1]{\left|#1\right>}\newcommand{\bk}[2]{\left<#1\middle|#2\right>}\newcommand{\bke}[3]{\left<#1\middle|#2\middle|#3\right>}$$
X
INFORMAÇÕES SOBRE DIREITOS AUTORAIS


As obras disponibilizadas nesta Biblioteca Digital foram publicadas sob expressa autorização dos respectivos autores, em conformidade com a Lei 9610/98.

A consulta aos textos, permitida por seus respectivos autores, é livre, bem como a impressão de trechos ou de um exemplar completo exclusivamente para uso próprio. Não são permitidas a impressão e a reprodução de obras completas com qualquer outra finalidade que não o uso próprio de quem imprime.

A reprodução de pequenos trechos, na forma de citações em trabalhos de terceiros que não o próprio autor do texto consultado,é permitida, na medida justificada para a compreeensão da citação e mediante a informação, junto à citação, do nome do autor do texto original, bem como da fonte da pesquisa.

A violação de direitos autorais é passível de sanções civis e penais.
Coleção Digital

Avançada


Estatísticas | Formato DC |



Título: DEVELOPMENT OF ORGANIC LIGHT EMITTING DIODES (OLEDS) FOR PHOTODYNAMIC THERAPY APPLICATIONS
Autor: ALINE MAGALHAES DOS SANTOS
Instituição: PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO - PUC-RIO
Colaborador(es):  MARCO CREMONA - ADVISOR
Nº do Conteudo: 66207
Catalogação:  12/03/2024 Idioma(s):  PORTUGUESE - BRAZIL
Tipo:  TEXT Subtipo:  THESIS
Natureza:  SCHOLARLY PUBLICATION
Nota:  Todos os dados constantes dos documentos são de inteira responsabilidade de seus autores. Os dados utilizados nas descrições dos documentos estão em conformidade com os sistemas da administração da PUC-Rio.
Referência [pt]:  https://www.maxwell.vrac.puc-rio.br/colecao.php?strSecao=resultado&nrSeq=66207@1
Referência [en]:  https://www.maxwell.vrac.puc-rio.br/colecao.php?strSecao=resultado&nrSeq=66207@2
Referência DOI:  https://doi.org/10.17771/PUCRio.acad.66207

Resumo:
This work aimed to develop Organic Light Emitting Diodes, OLED, for applications in photodynamic therapy. Photodynamic therapy is a treatment that basically uses a photosensitizer and light. When irradiated, the photosensitizer produces reactive oxygen species that destroy cells such as fungi, viruses, bacteria and tumor cells. This work is dedicated to the fabrication, characterization and tests of OLEDs as light sources for photodynamic therapy, PDT, representing an alternative to classical forms of medical treatment. As a way of testing the performance of the devices, PDT tests were carried out. These tests consist of using a probe sensitive to the presence of singlet oxygen (1O2). The probe used was DPBF which, in the presence of 1O2, breaks one of its aromatic rings. This effect can be followed by the decay of the intensity of the probe s absorption peak. The time interval between each measurement is set on the measurement, it is possible to infer the probe decay in order to compare the performance of the devices. To validate the test, a reference study was carried out using a commercial LED with an emission peak at 658nm. This step was fundamental for understanding the conditions that the light sources should have so that the tests could be carried out in times similar to the treatments involving photodynamic therapy. After that, the work consisted of manufacturing OLEDs with three types of emitting layers: fluorescent, phosphorescent and TADF. The emission layers chosen were: Alq3: DCM2, Bebq2:Ir(pic)3, BCPO: Ir(fliq)2acac and mCP:TXO-TPA , whose emission band is similar to the absorption band of the photosensitizer used, blue of methylene. In the first part were manufactures OLEDs with a small area, 3mm2 . After choosing the structures, fabrication and electrical characterization measures, the PDT tests were carried out. For the initial tests, two OLED power supplies were used, AC and DC mode, in order to evaluate the performance of the devices in different configurations. Highlighting the emitting layer OLEDs Alq3: DCM2 and Bebq2:Ir(pic)3 (in DC mode) and BCPO: Ir(fliq)2 acac (in AC mode), as they managed to stimulate the photosensitizer methylene blue to produce enough singlet oxygen to decay the peak absorption of the DPBF probe in the time interval of the PDT assay (30 minutes). On next step, the OLEDs selected were one with the emitting layer Alq3: DCM2 and Bebq2: Ir(pic)3 with the objective of testing the performance of the devices with an active area of 27mm2 , called large area. Introducing featured devices Bebq2:Ir(pic)3. Comparisons between large and small area OLEDs were also made in power loss (percent) over time and in PDT tests. As the best performance was obtained with the large area, this structure was used in the manufacture of OLEDs Bebq2: Ir(pic)3 on commercial conformable substrates of bacterial cellulose(BC), polyether block amide (PEBAX) and polyurethane (PU), functionalized in LOEM, and polyethylene terephthalate( PET). This research is innovative in Brazil and highly interdisciplinary as it involves the study of architecture, fabrication, characterization and tests in PDT and has the possibility of involving the synthesis of new materials and in vitro and in vivo tests. This work is also the beginning of a new line of research with biological application at LOEM group.

Descrição Arquivo
COMPLETE  PDF
Logo maxwell Agora você pode usar seu login do SAU no Maxwell!!
Fechar Janela



* Esqueceu a senha:
Senha SAU, clique aqui
Senha Maxwell, clique aqui