In the last decades, the business environment has been undergoing several transformations, influenced by the consequences of globalization, the evolution of digital media, the impacts on the environment, among other aspects. This scenario imposes significant challenges for the companies, such as the rise of the so-called Lifestyle Brands, brands that build deep connections with their users through purposes, values and principles, often linked to ESG factors (Environmental, Social and Governance). As a growth and defense strategy, several large companies have been acquiring Lifestyle Brands in different segments of products and services, which creates challenges and opportunities, from a marketing management point of view, for companies, as well as for the new brands. The present study sought to identify and explore these issues, as well as pointing out managerial contributions to companies and brands, based on in-depth interviews with a panel of experts formed by marketing professionals who worked in the management of Lifestyle Brands during the transition period of the brands to the new company. Through the interviews, it was possible to point out and analyze the main challenges faced, which include, mainly, the potential impacts on the authenticity of the brand; the risks associated with the internal prioritizations made by the new company; the tensions generated between short-term and long-term decisions; and the possible different business models between the brand and the company. Regarding the opportunities, the highlights were the potential learning and influences of Lifestyle Brands on other company brands; and the synergies and expansions that the new company can provide for the acquired Lifestyle Brand.