The present work aims to analyze how lupus interferes in the pregnancy experience of these women. It is classified as a chronic multisystem disease of an autoimmune nature known for its unpredictability, periods of remissions and relapses. Pregnancy for women with lupus is considered to be at high risk and elements of systematic planning, as they may present with recurrent abortions and the activation of the disease during the gestational period. When discussing pregnant women with lupus, we will emphasize how their experiences in relation to pathology, sexual and reproductive health, and motherhood, where these are permeated by family relationships. In this perspective, the specific objectives of this work are configured: 1) Discuss the meanings of motherhood for pregnant women with autoimmune disease living with lupus; 2) Check how family relationships are expressed in terms of the care and support of women with lupus; 3) Discuss how pregnant women with lupus live with their pathology. The methodological path of this work sought to understand these perspectives in the daily lives of five women in the experience of this scenario. As investigation procedures, we use semistructured changes that were carried out through a virtual platform. The results point to the importance of family relationships when we talk about pregnant women and lupus. In addition, we think about the existing fear in relation to the consequences of pregnancy and motherhood, and also the descent of women and groups of women who live with lupus to live with the pathology. We highlight the indispensability of planning and implementing public policies and the expansion of studies on lupus.