A growing concern in civil construction is to obtain structures that are more resistant, rigid and economically feasible. This study aims to evaluate the behavior of steel-concrete columns of composite section, through numerical modeling. The studied cross-sections were composed of two rolled I profiles, and other with C-lip channels, connected by I profiles, and filled with reinforced concrete. The ABAQUS software was used to evaluate the structural behavior of the columns subjected to flexural, compression and eccentric compression loads. The model was calibrated through experimentally obtained data from previous studies, and results provided by the Brazilian National Standards, and it was able to properly reproduce the moment-displacement and load-displacement curves. The obtained resistances from the numerical models were greater than the ones expected by the theoretical solution, especially under compression load. In order to evaluate the economic feasibility of the proposed composite model, a design example of an industrial shed was conducted, and it showed a significant increase in moment of inertia when compared to steel-only box sections, which resulted in savings of up to 11 percent in equivalent mass of steel. Finally, a parametric study was made to investigate the influence of the number and disposition of the connectors, and the contribution of the concrete resistance and reinforcement s diameter in the strength of the columns.