The objective of this research is to investigate the stability mechanisms of castellated beams and the interaction between lateral-torsional and compression tee local buckling modes. A verification of the strength capacity of castellated beams is carried out. Subsequently, an approach based on the Direct Strength Method is proposed for the design of these beams. The treatment of failure modes by current standards and design guides is unclear when considering possible interactions between buckling modes, thus there is a need for more studies and for the development of a design method that takes into account these effects. Firstly, a comprehensive study of 197 simply supported Litzka castellated beams under pure bending moment is carried out. The study involves finite element analyses considering both linear behavior and nonlinear behavior that, which included both material nonlinearity and geometric imperfection. The models are then validated. After computing the moments associated with critical local and global failure modes, and the ultimate moments, along with their respective modes, an approach based on the Direct Strength Method is performed. Equations that consider the interaction for nominal moments prediction are obtained through regression. The developed equation is then compared with current standards procedures. The results show that the proposed equation predicts better values for strength prediction in all cases, especially those in which local and/or interaction failure modes govern the behavior of the beam. The results also show that some of the procedures suggested in standards and guides for the design of castellated beams under flexure, either underestimate or overestimate the failure moment.