There has been an increasing global tendency in the adoption of Building Information Modeling (BIM) paradigm for the implementation of Architectural, Engineering, and Construction (AEC) projects. In Brazil, a governmental nominated commission is studying how to disseminate BIM as applied to governmental projects. At the same time, Structural Optimization (SO) has received a lot of attention in civil engineering applications to reduce material and enhance structural performance. The purpose of this work, thus, is to understand how SO can be inserted in a BIM project, specifically analyzing the interface between architects and structural engineers. The investigation included a Systematic Literature Review (SLR) to comprehend the current scientific scenario in these areas. It was observed that there is a scientific gap in works that connect SO and BIM. To help fill this gap, an Information Delivery Manual (IDM) structure was developed which maps the information flow to connect architects and engineers through SO in a BIM environment. The proposed methodology was applied to three experiments of increasing complexity. It was verified that SO can be inserted in a BIM project once interoperability and collaboration issues are improved. To validate the structural solutions based on the SO results, detailed analysis using Finite Element Models (FEM) were developed and analyzed. It was found that the solutions were structurally acceptable according to current design codes. However, they may require advanced construction techniques to be economically feasible. It is worth pointing out that this study was limited to usual building projects in the early stages of the design.