The aim of this work was to study the chemical functionalization of titanate nanotubes (TTNTs) with 3-aminopropyltriethoxysilane for application as a reinforcement of nylon-11 matrix nanocomposites in order to increase the dispersion and compatibility between nanotubes and the polymer matrix. Two samples with high and low sodium content (TTNTs/H and TTNTs/L, respectively) were functionalized in a solution of ethanol/water 95/5 v/v and water to assess the effect of the reaction medium on the amount of silane grafted on the TTNTs surface, expressed as the density of aminopropyl groups per nm2 (NR). The functionalized nanotubes were characterized by infrared spectroscopy, CHN elemental analysis, measurement of the specific surface area, thermogravimetric analysis, scanning electron microscopy and transmission electron microscopy. Nylon-11 matrix nanocomposites were manufactured by microextrusionmicroinjection and reinforced with 0.5, 1.0 and 2.0 wt. percent of pristine and functionalized nanotubes. Finally, mechanical and thermal properties as well as the microstructure of the nanocomposites were evaluated. The results confirmed the Ti-O-Si covalent bond and showed a higher NR value when the silanization was performed in ethanol/water for both TTNTs. The nanocomposites reinforced with 2 wt. percent of TTNTs/H (silanized in water) and with TTNTs/L (silanized in ethanol/water) presented an enhancement on the Young s modulus of 11 and 13 percent, respectively when compared with the neat nylon-11. The yield properties of these nanocomposites decreased, but the degradation temperature was improved with the incorporation of the functionalized nanotubes. The nanocomposite prepared with 0.5 wt. percent TTNTs/L silanized in ethanol/water showed the best dispersion.