Urbanization is a global phenomenon and occurs on a planetary scale, with unequal rhythms and different paths, but leading to the same complex and diverse reality: the construction of a planet of cities. Nowadays, we see a process of urbanization that we can describe as global and accelerated, but it does not develop in a balanced and efficient way on the territory. The progressive concentration of the population in large urban agglomerations, the accelerated and sometimes uncontrolled growth of megacities are spatial effects of the current process and trends of urbanization. Nevertheless, the majority of the world urban population lives in small and medium-sized cities and forecasts indicate that these centers will continue to increase their population. In the last decades, it has been observed that in several Latin American countries, the settlement model is changing and there are areas of economic importance, where decades ago, they used to be entities without much population dynamism. Despite this, there are not many international or regional studies on the smaller cities in urban systems.