A design problem is the manifestation of one or more inappropriate design decisions that negatively impact non-functional requirements. For example, the Fat Interface, a problem that indicates when an interface exposes non-cohesive services, hampers the extensibility and maintainability of a software system. Despite its harmfulness, identifying a design problem in a system is difficult, especially when the source code is the only available artifact. Although researchers have been investigating techniques to help developers in identifying design problems, there is little or no knowledge about the process of identifying design problems. For instance, code smells, microstructures that are a surface indication of design problems, have been used in several techniques to support developers during the design problem identification. However, there is no knowledge if code smells suffice to help developers to identify design problems. In particular, no study has tried to understand how developers identify design problems in practice. Thus, in this thesis, we have conducted a series of studies to understand design problem identification. In our two first studies, we investigated the role that code smells play in supporting developers during the design problem identification. Our results indicate that code smells are relevant for developers in practice; for instance, they are relevant to indicate elements that need to be refactored. However, we found that code smells, despite their relevance, do not suffice in helping developers to identify design problems. In this vein, we conducted another study to investigate what indicators developers use in practice, and how they use them. This study resulted in a theory about how developers identify design problems in practice. For instance, the theory reveals the indicators that developers use, how they use these indicators, and the characteristics of such indicators that are perceived as helpful by developers. The results found by our studies provided us with a better understanding of the process of identifying design problems thitherto nonexistent. Moreover, our findings pave the way for the elaboration of more effective techniques to identify design problems in the source code.