Reprocessing of medical supplies is an essential process to maintain the hospital s functionality. The Central Sterile Supply Department (CSSD) is the hospital technical support unit oriented by specific norms and regulations aimed at reprocessing the materials, having as main objective the prevention of infections and delivery of safe medical articles. However, it is an area of low visibility and with high variability in the sterilization process and there is not a model of decision making that has both the requirements of the assistance models established by the legislations and the design aspects of the management and operations management. In this way, the present research aims to elaborate a reference model based on the project operation categories in order to help the manager to design a CSSD. The research objective is achieved through the following specific objectives: a) survey of the reference theory; b) survey and identification of regulatory instruments; c) field research in a complexity levels representative CSSD; d) analysis and synthesis of the operating logic in the light of the categories of operations; e) definition of the structure of the reference model; f) validation of the model with specialists; g) model refinement; and h) model application. The proposal of the reference model of requirements, based on legislation and production management, is the main contribution of the research.