This study aimed at understanding the meaning of work for people with an acquired disability, and its eventual changes over their professional careers. In order to achieve this goal we have interviewed ten people, in the labor Market, that have acquired a disability between adolescence and adulthood. Taking internal and external factors into account, our results suggest that the meaning of work can change throughout a person s lifetime. Recurrent meanings of work exposed in speeches, like pleasure and vocation, did not appear as consequences of disability acquisition, but as part of their identities. Disability impact made interviewees search for new ways to fulfill their vocation and find pleasure through work. The disability did not appear as an interference factor on preferences and interests, but in the way interviewees used to see it, making them see work in a new way. Among the different meanings of work that emerged from disability, the most common were: work as a way to deal with disability; as a place of social interaction; as a way to affirm an aptitude; and a way to achieve autonomy and empowerment. Generation of value through work was also considered fundamental, by high quality production, with its respective demonstration and recognition, or by positive social impact. Affective relations were considered more important, than the work environment. Remuneration was reported as consequence, but not as a factor generating meaning, likewise career progression.