Among the various pregnancy intercurrences, the pregnancy loss causes, in women who experience the process, significant emotional distress. The Gestational Trophoblastic Disease is one of several diseases that implies on the loss of pregnancy. However, what makes the molar pregnancy of particular interest to our study, is its characteristic of submitting the women who suffer this disease to two different set of events: the loss of pregnancy itself, due to severe genetic malformations of the fetus, and to a further event, where the Molar Pregnancy usually evolves or implies in some kind of cancer, that consequently will submit it s patients to the strict protocols of treatment of neoplasms. Our experience with Gestational Trophoblastic Disease, comes from working, since 1998, at the reference center of the State of Rio de Janeiro to this disease, located at the 33th ward of the Maternity Hospital Santa Casa da Misericordia of Rio de Janeiro, where every week a group of about 70 women with Gestational Trophoblastic Disease are admitted and treated. This research aims to study the emotional impact on women facing the molar pregnancy disease and its psychosocial implications. To achieve this goal, we conducted a series of exploratory qualitative interviews, involving five women who were followed up weekly at the clinic of molar pregnancy, no more than three months after they had been diagnosed. The discursive material collected from the interviews was analyzed. From this analysis four categories of issues emerged : 1) feelings and perceptions; 2) fear of disease and death; 3) Family Support and Referral Center; and 4) Relationship and desire for motherhood. We noted that each of these categories of issues imposes its uniqueness to the process of loss, which derives from the particular relationship with the pregnancy and with the expectations related to the expected child fed by the women . Moreover, the interviews indicated that the pregnancy loss caused by Trophoproblastic Gestacional Disease, is full in suffering related to the secondary disease acquired, causing women to experience the sense of Little-value and failure in their social role related to perpetuating the especies. We also verify that the Family Support and Referral Center, with its emphasis on psychological support, plays a key role in preventing the complications of the loss and grief arising from molar pregnancy.