Computational methods in engineering are used to solve physical problems that do not have analytical solution or their perfect mathematical representation is unfeasible. Numerical techniques, including the largely used finite element method, require the solution of linear systems with hundreds of thousands equations, demanding high computational resources (memory and time). In this thesis, we present a plugin-based framework for large-scale numerical analysis. The framework is used as an original tool to solve topology optimization problems using the finite element method with millions of elements. Our strategy uses an element-by-element technique to implement a highly parallel code for an iterative solver with low memory consumption. Besides, the plugin approach provides a fully flexible and easy to extend environment, where different types of applications, requiring different types of finite elements, materials, linear solvers, and formulations, can be developed and improved. The kernel of the framework is minimum with only a plugin manager module, responsible to load the desired plugins during runtime using an input configuration file. All the features required for a specific application are defined inside plugins, with no need to change the kernel. Plugins may provide or require additional specialized interfaces, where other plugins may be connected to compose a more complex and complete system. We present results for a structural linear elastic static analysis and for a structural topology optimization analysis. The simulations use elements Q4, hexahedron (Brick8), and hexagonal prism (Honeycomb), with direct and iterative solvers using sequential, parallel and distributed computing. We investigate the performance regarding the use of memory and the scalability of the solution for problems with different sizes, from small to very large examples on a single machine and on a cluster. We simulated a linear elastic static example with 500 million elements on 300 machines.