The increasing use of discrete event simulation in production systems led the specialized companies to develop and to offer market a wide range of software with different features and costs. Thus, the correct choice of a simulator is extremely important, since an incorrect selection can lead to negative consequences in the results and hence on organizational performance. In this context, it was possible to identify that there is a gap to be met regarding the selection of simulation software that consider the needs of users. Consequently this thesis aims to present a methodology structured in two stages for the evaluation and selection of discrete event simulation software for manufacturers. In the first stage it was proposed an evaluation framework of operational processes based on maturity models. In this way, it will be possible to analyze whether the company under study has some of the basic conditions to adopt the computer simulation. In the second stage it was proposed a set of criteria as a basis to analyze and select the simulation software. Selection will be made through the use of AHP (Analytic Hierarchy Process) used in multi-criteria problem solving. Both the assessment of operational processes as a set of criteria weighing will be made through the use of questionnaires in order to identify the specific needs of the processes. Four practical applications were made with the proposed model and its results were presented describing the analysis performed during the execution of the work. Four practical applications were made with the proposed model and its results were presented describing the analysis performed during the execution of the work.