Recently in Brazil, there was a great offer of patented additives (enzymes) to the highway works as solution to soil stabilization. However, they are sometimes rejected because there are not enough theoretical knowledge to prove such use, and because researchers do not see it as a promising research field. Anyway, these products have been traded, and frequently, the counties and states waste their resources by choosing a solution that is not well studied yet. In the present research, it was studied the use of additives applied in some soils, aiming its stabilization. For this study, it was used a portable traffic simulator (Load Wheel Test - LWT), used to evaluate the effect of the compression and deformation characteristics of asphalt layers coatings. For that, it was used a set of several accessories for molding the specimens in 380x50x10mm format and can be easily adapted to the equipment. Were investigated three different types of lateritic soils, three different types of enzymes, soil in the pure state and treated with three dosage variations in the application of enzymes and four curing times of the specimens. These specimens were molded and tested in order to obtain a series of experimental results was followed a rigorous care in production to ensure equal and, subsequently, be able to compare the results of the soil treated with enzyme and the soil without any treatment. It was concluded that the soils improved with enzyme were effective for application in pavements, with their behavior distinguished by the type of soil, type of enzyme content and it application, in some results showing improvements over 500 percent compared to the soil in the pure state.