In life of Jesus of Nazareth stands out the presence and action of Holy Spirit over his messianic ministry to affirm the centrality of relationship between christology and pneumatology. Jesus Christ is the most important of all reality mystery, revealed in a unique way, unrepeatable and unsurpassed in the Spirit. The path of Spirit in Christ event is the main argument of this thesis. The theological horizon with the human reality are challenges to face today. For this purpose, it was first placed highlighted the relationship between Christ and the Spirit in the NT, in key moments, where is the manifestation of Spirit in the life of Christ in the incarnation, in his baptism and the paschal mystery. In all three events the active presence of Spirit reveals the divine and human constitution of Christ and the universality of salvation. After the biblical witness and post-biblical highlighted the presence of Holy Spirit in the renewed attention of Vatican II in its christological, pneumatological and ecclesiological aspects. The Council represented a renewal of Church, though with limitations and difficulties to articulate its contents. The conciliar texts boosted the post-conciliar theological production valuing the pneumatological Christology, highlighting the works of Yves Congar, Walter Kasper and Marcello Bordoni. The post-conciliar reflection particularly affected theological position in Latin America, so it was important to analyze the Spirit s presence in the Latin American christology. Finally, some points emerge in contemporary times, indicating the need for theological reflection to deepen the pneumatic dimension of Christ s mystery.