Reservoir simulation models are subject to uncertainty in a wide variety of its inputs. This uncertainty is a result of the heterogeneity of the geological formations, data measurement errors, and petrophysical, structural, and fluid transport in porous media modelling. An accurate uncertainty quantification requires, in most cases, a large number of simulations, which is unviable considering the time it takes to simulate large scale models. On the other hand, a proper uncertainty assessment, increases the robustness of the decision making process for the oil field management. To this end, the method of Polynomial Chaos Expansions (PCE) was studied. PCE is a fast paced convergence technique, used to analyze the uncertainty propagation of the input parameters all the way to the output of the model. Through PCE is possible to represent the response of an oil reservoir simulation model as a polynomial, built from a function basis, that depend on the probability distribution of the uncertain input variables. Furthermore, when the relationship between the input and output parameters of the model has a non-polynomial component, the algorithm of Genetic Programming (GP) can be used to represent this dependency by more elaborate functions or operators. GP is a symbolic regression algorithm, capable of finding an explicit expression that approximates the output of a reservoir simulation model, with prior knowledge of the probability distribution of the input parameters. In this work, the two previously mentioned techniques were applied in a reservoir simulation model, based on the oil field PUNQ-S3, considering up to twenty three uncertain parameters during a simulation period of 13 years. An uncertainty analysis of the output of the simulator was conducted, calculating the entire probability distribution. The results were compared to the Monte Carlo simulation method, presenting a satisfactory performance in terms of accuracy and computational cost. Both techniques show adjustment levels higher than 80 percent, with a considerable small amount simulations.