Pipelines are efficient and safe systems for the transport of oil and gas. The study of the load capacity of these systems under functional conditions which include the transport of aggressive products under high temperatures and pressures has gained larger interest due to the severe operation conditions and growing needs for maintenance and adaptation of the existing pipelines to these conditions. However, the presence of defects and imperfections in pipe segments may lead to reduction of resistance and eventually to failure. The scope of this dissertation is the prediction of the behavior of pipelines subjected to combined load conditions and sequences till collapse, reproducing those which occur on field and in laboratory tests. Axial forces, internal pressure and bending are applied to the model in order to reproduce thermal effects, operating pressure and ground movements. In the case of soil settlement the pipeline may be subject to bending effects which result in excessive curvatures. As a consequence local buckling occurs with the development of wrinkles. Under these conditions strains above those recommended in the codes can take place.Due to the three dimensional nature of the problem the investigation of the local buckling phenomena, requires the understanding of the behavior shells under large displacement and large strain conditions in elasto- plastic regime.In the present work some models are developed for the prediction of the behavior of pipelines subjected to combined loading. Validation of these models allows us to accompany and establish experimental programs. Some reference laboratory results available in the literature are included. Aspects of the modeling such as boundary and loading conditions, material modeling and solution procedure are addressed. The development of wrinkles and large deformations brings into the model additional aspects such as the presence of self-contact areas. Numerical examples are analyzed using the commercial finite element program ABAQUS.