This work presents concepts used in the assessment of structural reliability in order to calculate the probability of failure of a structure as it serves the purposes for which it was designed during their lifetime. A methodology for structural reliability analysis has been developed for the pipeline transportation of oil and natural gas, although, this methodology can be applied to different equipment. The methodology allows the coupling of different events that may occur in the life of a structure. The events can be understood as defects by corrosion, damage by third parties, incorrect operations, etc. or events related to inspection of the structure, pipeline or equipment. Each event is described by a limit state function of the type capacity vs. demand. The coupling of these states limit is given by the union or intersection of these (series systems, parallel systems, or combination of them). The analysis is reduced to system reliability computation and the solution is reached using the integration of the standard multinormal function and first order reliability methods- FORM to calculate the probability of failure of system. The multinormal integral is computation using the product of conditional marginal method-PCM and the improvement of PCM method. The results obtained of this methodology may be useful in the generation of inspection plans and in predictive and risk analysis. The methodology described can be implemented in a structural reliability management program. The program should be able to coupling all events that occur in the lifetime of a pipeline or structure.