The economic competitiveness has led companies to seek new solutions through the use of Information Technology (IT) to achieve competitive advantages over their competitors. The use of IT enables companies to have greater control in managing their processes and thereby achieve productivity gains, reduce operating costs and improve customer satisfaction. The present study aims to present and analyze the process of implementing a Warehouse Management System - WMS on logistics activities in a distribution center (DC). There will be a case study, consisting of a post-implementation review of the system in a distribution center for drugs through implementation of a Performance Measurement System Logistics in order to identify improvements and gains in the activities of a warehouse. Within this context, are also identified risks and resistance in the implementation of WMS. The methodology used for this thesis is qualitative in nature, consisting of a literature review, and exploratory character, through field research, visits to the company in the are study and interview. The result of this study is an analysis of performance improvement after applying WMS, noting advantages of IT for logistics distribution such as a higher level of accuracy and time reduction.