In the Exploration and Production (EeP) of oil, the detailed study of reservoir characteristics is imperative for the creation of simulation models that adequately represent their petrophysical properties. The availability of an appropriate model is fundamental to obtaining accurate predictions about the reservoir production. In addition, this impacts directly the management decisions. Due to the uncertainties inherent in the characterization process, along the productive period of the reservoir, its corresponding simulation model needs to be matched periodically. However, the task of matching the model properties represents a complex optimization problem. In this case, the number of variables involved increases with the number of blocks that make up the grid of the simulation model. In most cases these matches involve empirical processes that take too much time of an expert. This research investigates and evaluates a new hybrid computer technique, which combines Genetic Algorithms and Multipoint Geostatistics, for the optimization of properties in reservoir models. The results demonstrate the robustness and reliability of the proposed solution. Unlike traditional approaches, it is able to generate models that not only provide a proper match of the production curves, but also satisfies the geological characteristics of the reservoir.