One of the main challenges of the petroleum industry is the drilling in salt domes, and to well design the drilling is necessary to analyze the impact of the drilling fluid used in salt regions. To make this analysis possible, it is necessary to know the diffusion coefficient D of the salt in this fluid. For this reason this research looked for a method to determine the binary diffusion coefficient D of salts in liquids not only accurately, but in a reasonable time. We chose to use the Taylor Dispersion Method. This technique has been used for measuring binary diffusion coefficients in gaseous, liquid and supercritical fluids, due to its simplicity and accuracy. In the method, the diffusion coefficient is determinated by the analysis of the dispersion of a pulse of soluble material in a solvent flowing laminarly through a tube. This work describes the theoretical basis and the experimental requirements for the application of the Taylor Dispersion Method, emphasizing the description of our experiment. A mathematical formulation for both Newtonian and non-Newtonian fluids is presented. The relevant sources of errors are discussed. The experimental procedure and associated analysis are validated by applying the method in a well known system: NaCl in water. The efficiency of the mathematical model and the experimental apparatus has been proved by the preliminar results. The experiment is being validated and soon will be able to be used by Petrobras.