The Brazilian retail market has been facing the same players concentration process, as can be seen in many others sectors around the world. The Brazilian economy stabilization and players with more professionalism, require companies to have the excellence in their operations. The investment in stock is too high for this sector, because there are lot of products, located in many stores, distribution centers, products with a high average costs price and many of them have with a low trn over around the time. Seasonal factors and new products launch, changes the demand across the time and requests a quick response to avoid loses. The difference between loss and profit of the retailers can be found in the supply management cycle. This dissertation shows the thoughts from some researches related to the subject been studied. After, the information about the market and the company are described, follows by the supply chain of the drugstore chain analysis. Based on the theory and the problems identified, an alternative way to manage and optimize the supply system is suggested. The model was tested and the results will be show in the end of the dissertation.