Spirituality and religiosity (S/R) have been widely investigated as health promoters. The pandemic caused by COVID-19 generated and/or aggravated several emotional problems in Brazilians, such as depression and anxiety. For this reason, in this research, symptoms of depression and anxiety were evaluated in terms of E/R levels, as well as private practices of prayer and attendance at religious spaces. Data was evaluated through an online protocol with 1342 people. Most are female, with graduate degrees, and from different religious traditions. The BDI-PC was used to screen for depression. The STAI-T-E measures anxiety. A SRCOPE-14 to analyze religious-spiritual coping strategies. A sociodemographic questionnaire to collect information regarding E/R and data such as sex, age, religion, education level, and region of Brazil. The groups were divided according to the E/R gradation and named as Very Spiritual, Not Spiritual, Very Religious, and Not Religious. About prayer practices, the groups were separated into Group that Never Prays, Group that Always Prays. As for attendance at churches, temples, terreiros, centers, and others, they were divided into two groups, named: Never attend church and Always attend church. ANOVA, in turn, demonstrated in this research that there are significant differences in individual prayer practices (F(8.1329) = 8.773, p less than 0.001). People who pray alone showed less depression (delta =-1.097 p less than 0.05) than those who indicated that they never prayed. It can be observed that the group of people who considered themselves very spiritual had a lower mean on the BDI-PC (M=2.57), SD=2.88) than the group who indicated not at all spiritual (M=4.29, SD=4.07, p less than 0.001). A correlation was performed to verify the association between religiosity and spirituality. In summary, the data suggest that E/R may be associated with better health conditions.