Anxiety disorders affect thousands of people all around the world, being represented as the most common of mental disorders. Anxiety is associated with a number of behavioral and physiological responses when faced with aversive stimuli. These responses provoke neuroendocrine actions involving the activation of the sympathetic nervous system (SNS), the hypothalamic-pituitary-adrenal axis (HPA) and the renin-angiotensin system (RAS). Studies on animal models allow for a better understanding of the neurophysiological and behavioral mechanisms associated with pathologies observed in humans. The Carioca High Freezing (CHF) and Carioca Low Freezing (CLF) are two conditioned strains of rats that present, respectively, high or low levels of anxiety-like responses. The present study investigated the effects of Losartan and Valsartan, both angiotensin II receptor blockers, on the modulation of anxiety-like behaviors of CHF, CLF and control rats. Neither chronic treatment of Losartan nor acute treatment of Valsartan yielded significant effects on anxiety measurements in the contextual fear conditioning, open field and elevated plus maze tests. Thus, our findings suggest that at the doses and durations of treatment tested, administration of these antihypertensive drugs did not play a modulating role of anxiety-like behaviors in CHF and CLF animals.