Cystic fibrosis is a genetic disease caused by mutations in the CFTR gene, which involves changing the transport of ions across the membrane of various organ cells, increasing the amount and viscosity of the mucus, sweat and pancreatic secretions. The main consequence is lung damage, characterized by frequent infections and respiratory failure. Several studies have been developed over the years with the intention of discovering drugs that can act as modulators of CFTR, improving the lung function of these patients. The present work aimed to synthesize derivatives of 3-phenylindeno[1,2-d [1,2,3]triazol-8(3H)-one, 3-phenyl-3,4-dihydro-9H-[1,2,3]triazolo[4,5-b]quinolin-9-one and 3-(1-phenyl-1H1,2,3-triazole-4-carbonyl)quinolin-4(1H)-one to characterize the relationship structure of these compounds as enhancers of CFRT. For the synthesis of 3-phenylindeno[1,2-d][1,2,3]triazol-8(3H)-one, the 2-bromoacetophenone was initially used to produce the (E)-3-(dimethylamino) -1- (2-nitrophenyl) prop-2-en1-one through the Gold reagent obtained from the cyanuric chloride. The key step of obtaining the triazoles was accomplished by a cycloaddition reaction between the (E)-3-(dimethylamino)-1-(2-nitrophenyl) prop-2-en-1-one and the aryl azides azido-benzene, 1-azido-4-bromo-benzene, 1-azido-4-nitrobenzene and 4-azido benzoic acid. Four compounds in yields between 20 percent and 50 percent were obtained. Attempts were made for intramolecular cyclization catalyzed by palladium in the presence of phosphines, but the expected product was not obtained. To obtain 3- phenyl-3,4-dihydro-9H-[1,2,3]triazolo[4,5-b]quinolin-9-one, first It was obtained the intermediate (E)-3- (dimethylamino)-1-(2-nitrophenyl) prop-2-en-1-one through cycloaddition reaction with the azido-benzene gave the triazole in 30 percent yield. The proposal would be the reduction of the nitro group to amine, and subsequent replacement of the amine with azide, to make the intramolecular arylation of triazole via photoredox catalysis. To obtain 3-(1-phenyl-1H-1,2,3-triazole-4-carbonyl)quinolin-4(1H)-one, aniline and diethyl ethoxymethylene malonate were used as precursors to synthesize ethyl 4-oxo-1,4-dihydroquinoline3-carboxylate, which was obtained in 50 percent yield. An addition reaction of alkyne followed by the elimination of ethanol was performed to obtain the 3-(1-phenyl1H-1,2,3-triazole-4-carbonyl)quinolin-4(1H)-one with ethynyltrimethylsilane and then carried out a click reaction with azides. All compounds obtained were characterized by 1H-NMR and 13C-NMR.