The study examines climate change in the Amazon, with a focus on extreme droughts in Manaus and their impacts on urban logistics. The primary objective is to reveal the effects of climate change and extreme droughts on Manaus s urban logistics and explore possible solutions for adaptation and resilience. Extreme droughts pose a significant challenge to urban logistics, directly affecting the quality of life of the population and the local economy. The research adopts an interdisciplinary approach, integrating knowledge from civil engineering, urban planning, environmental sciences, and public policy to comprehensively and holistically address the challenges faced. Data collected from various sources, including public managers and transportation companies, provided a solid basis for analysis. The results indicate that extreme droughts strongly affect Manaus s urban logistics, highlighting the lack of adequate infrastructure, particularly on land. The study emphasizes the urgency of improving infrastructure and adopting adaptive measures to mitigate environmental impacts. This includes expanding the road network, implementing and analyzing a rail network, and developing more resilient and adaptable infrastructure. Collaboration between the government, community, and private sector is essential to addressing these challenges and promoting urban resilience in Manaus.