The activity of creation of an interactive digital interface for the internet involves issues concerning the representation of its elements (task to be accomplished by the designers of that interface), significance of those elements and the decoding of that interface by the users. Semiotics, the science of signs, comes as a meticulous look on mentalist subjects and human subjectivity. This research seeks to demonstrate that a website conceived with the implementation of the principles brought from Peirce Semiotics, allied to usability interface methodologies, would become more successful among its public - by understanding the behavior, fruition, proficiency and the public s objectives. The focus of this research relapses on Brazilian portals and the speaker of Portuguese language public. The concepts, evaluations and obtained results can be extended to other interactive artefacts and diverse publics. Several sciences and methodologies that act in the usability verification of interactive digital medias, the cognitive component and the human learning were observed. A data set based on the user`s impressions about the home page of two specific information portals was presented, in addition to the comments collected in interviews with active designers in the creation of portals aimed at the Brazilian public. The home pages were analyzed in accordance with the principles of the usability (several authors) and the Peirce semiotics, in the work of Santaella. The results of the data collected and the analysis were used in the creation of advices for a design that glimpses issues from the semiotics and from the interface usability.