The creation and management of new businesses demands, more and more, strategies connected to sustainable indicators and results. In the search to generate long-term value in these models - based on social, environmental and economic dimensions -, and in order to also guarantee greater competitive levels for businesses, researchers and practitioners have been making efforts to reaching these goals through the constant use of innovation. Innovation that enables high standards of sustainability are located, specially, in the incorporation of organizations of business ecosystems. As a consequence of this union between innovation and sustainability is the generation of what is conventionally called innovation in sustainable business models. The advent of such models rises an interesting debate: are the factors that compose the ecosystems orquestration - known as absorptive capacity, innovation appropriability and network stability (which binds the firms) - capable of positively tempering the relationship between the integration of businesses in ecosystems and the innovation in sustainable business models? Through the theoretical reference and the primary data of 302 companies of the Brazilian manufacturing sector analyzed by the modeling of structural equations, this dissertation combines subsidies to answer this question. As a result of the investigation performed, it is possible to notice the positive interference of the absorptive capacity and the innovation appropriability on the existing bind between the integration of firms in ecosystems and a greater level of innovation in sustainable business models.