The present work evaluates the changes in the microstructural and mechanical properties of an API 5L X80 steel tube due to the influence of heat input exerted during a welding procedure that used two sequential welding processes. The tubes were manufactured using the UOE process, from steel that was produced by controlled rolling without accelerated cooling. The welding was carried out on a 3/4 thick and 20 nominal diameter pipe, while it was held in a horizontal position in order to simulate field conditions, using a controlled short circuit GMAW process with CO2 (100%) gas shielding for the root pass and a flux cored arc welding process with Ar-CO2 (80% - 20%) gas shielding for the other passes. The evaluation of the mechanical properties was done by means of mechanical tests according to the API 1104 standard, in addition to the Vickers microhardness and Charpy V-notch tests. The changes in the microstructure of the Heat Affected Zone (HAZ) and the welded metal were evaluated by means of scanning electronic microscopy (SEM) and optical microscopy. The mechanical evaluation was unsatisfactory according to the API 1104 standard, while the tensile and Nick-Break test results were acceptable. The side bend test showed a crack in a specimen that exceeded the maximum acceptable value. The Vickers microhardness results were acceptable and the Charpy V-notch result, according to the DNV-OS-F101 standard, at a temperature of 0 °C, was unsatisfactory in the weld metal region of the over cap. The HAZ region showed greater energy of impact absorption compared to the base metal, at a temperature of 0 °C, even with existence of the microconstituent M-A.