Translation is a human endeavor defined by linguistic and cultural aspects. The purpose of this monograph is to analyze the possibility of crafting a domesticated Brazilian Portuguese translation of the Warhammer Horror novella The Colonel s Monograph (MCNEILL, 2019) that can accurately and consistently convey the culture of the Warhammer 40000 universe. This endeavor focuses on the understanding of translation as a graphological and intercultural practice (NORD, 1997), on the understanding of the notion of domestication in translation (VENUTI, 1995), and on the concept of culture-specific items (CSIs) and strategies for their translation (AIXELÁ,1996; NEWMARK, 1998). A brief literary overview of the Warhammer 40000 literary universe is also presented for contextualization purposes. The analysis revealed that the novella contains 188 different CSIs. A sample of 18 were randomly extracted from each type/class of CSIs defined by Aixelá (1996) and Newmark (1998). The analysis of Aixelá’s translation strategies revealed that 55 per cent of the CSIs could be processed by foreignizing strategies, while the other 45 per cent proved to be compatible with the application of domesticating translation techniques. Although more research is necessary to definitely confirm it, the presence of 45 per cent of domesticated CSIs is a promising evidence of the feasibility of crafting a domesticated translation of McNeill (2019).