This thesis analyses the effacement of the subject in the contemporary clinic, taking as example the construction of the discursive field of biological psychiatry. It inquires the construction of the field as a result of the battle for monopoly of scientific authority and qualification. It questions the predominance of physicalism regarding subject suffering and the medicalization of uneasiness. Throughout its chapters, the thesis discusses the development of individualistic values and the notion of the unconscious subject. It describes the intellectual path of psychiatry in order to unveil the tension between the physical and mental approaches. Examines the psychiatric project to reduce subjectivity in brain functioning. It analyzes critically the classification of mental disorders in order to associate it to a diagnostic inflation. The thesis shows that the biological psychiatry has faced scientific limits for the imposition of the physicalistic reading. These limits refer to the lack of evidences that confirm the premise according to which mental disorders are brain disorders. From the psychoanalytical point of view, the limit is given by the fact that the subject is a result of language and that, therefore, it is not possible to consider it as a double of the brain, or reduce it to universalizing diagnostic categories.