This study examines the dependence structure between the stock markets of Brazil, Chile, Colombia, Mexico and Peru and the commodity price, the global stock market and its volatility, and the U.S. economic-policy uncertainty index. The methodology employed is the quantile regression because it allows to exam the dependence in different quantiles of the returns distribution, that is, under different market circumstances. The results showed that there is dependence on the global stock market in all countries. In general, commodity prices also influence the stock markets of Latin America, with the dependence structure being often asymmetric. The U.S. economic-policy uncertainty index doesn t impact the stock markets of Chile and Peru, while the dependence structure is negative and asymmetric in Brazil, Colombia, and Mexico. Finally, the VIX index is not significant for the stock market returns in Brazil and Peru. As an additional contribution, the dependence of the brazilian stock market in relation to the Brazil economic-policy uncertainty index. The study identified that positive changes in the political-economic uncertainty index lead to declines in shareholder returns, when the market is bullish. The results of this study contribute to understand the movements of stock market returns in Brazil and other Latin American countries in relation to several factors, which are of interest to several stakeholders, such as international investors and portfolio managers.