Saint Thérèse of Lisieux, in an immanent and transcendent way, lives and witnesses her search for holiness in her mystical itinerary, which is called: Little Way. Through her evangelical smallness, she translates into her life and spirituality, the so-called Spiritual Childhood. As a child, the human being recognizing his weaknesses and limitations, can find in the merciful love of the Father the satisfaction and happiness that he so desire. Therefore, the Small Way as a human-spiritual path consists of a disposition of the heart that makes the person humble and small in the arms of God. In the Word of God, Thérèse of Lisieux finds the key to her vocation. She comes to understand that the highest gifts are nothing without love, and that charity is the path by excellence that leads people to God. Thus, her mission, in the heart of the Church, is to love the God-Trinity and to be a sign of this love on the face of the earth, above all for those who need it most. Her testimony is strongly marked by trust, abandonment and the merciful love of God. The Church recognizes her importance by granting her the titles of Patroness of the Missions and Doctor of the Church. The spirituality lived and described by Thérèse of Lisieux can bring considerable contributions to our time, especially when we bring it closer to the embodied mystique that occurs today, in everyday life and in the reality in which we are inserted. Her writings help reflection on universal fraternity and care for nature s goods, and inspire other mystics to travel her Little Way, thus becoming witnesses of the Mystery of the Living God present in the world and signs of hope in other lives.