This thesis starts from the idea that the perception of development, the colonization of the world of life and the instrumentalization of the subjects in modernity are associated with ways of perceive spatiality by philosophies, the (neo) positivist sciences and for a whole variety currents of thought constituted in modernity. It is believed here that all these conceptions of space practice an epistemicide of space, because, by intentionally ignoring praxis in the social space, directly interfere in the genesis of the conception of space as absent of contradictions. In this sense, is sought the analysis of the genealogy of a political epistemology in Geography from the incorporation of metaphilosophy, through the theory of alienation, in geographical thinking. The theory of alienation plays a role in reconstruction of the notion of space in the process of epistemological renew in geography, triggered from the critical geography of Marxist bias – once it establishes an ontological and epistemological rupture movement in geographical thinking - and this movement marked in updating philosophy of praxis (mataphilosophy) has repercussions practical-theoretical beyond geography since it allows us to shift the look at the object of study of this discipline for the understanding of spatialities of the reproduction of social relations of production.