It is urgent in a world where plurality is an intensely perceived reality, to discuss new standards for the missionary practice. The indigenous contexts, fruit of a long process of resistance to the traditional models of evangelism, generate in the new religious scene new modes of presence - not anymore as receivers of salvation but as vehicles of revelation, claiming new standards based on alterity, diversity, and dialogue. It is necessary to think over the ways to communicate the faith in Jesus Christ into specific cultures. Necessity still more urgent in a world which faces a ambiguous globalization process that, on one side, offer a kind of cultural homogenization and, on other side, generates new identity movements – so diverse, fragmented and plural. That is the case of the Quechua culture. For some interpreters it is on the verge of disappearance and, for others, it is reinventing itself. How to establish a dialogue between these minorities and the Christian faith? How to perform it in a new mode of enculturation and maturity? What would be the revelation elements in the Quechua culture and how would they enrich the Christianity as an expression of true Christian faith? These have been the questions asked all along this dissertation. We do not have the pretension to solve and present the whole process of enculturation among the Quechuas. Instead, we intent to contribute to the dialogue and mission among the Quechuas by deepening the reflection about the consequences of the encounter between Gospel and culture, trying to recognize the riches of native culture and religion as originating from God himself and trying to make them manifest to all readers. Therefore, this dissertation is a contribution and a token to the efforts of Indigenous theologies, by reflecting on the enculturation among the Quechuas and, at the same time, offering a defense and pledge to their autochthones cultures. The dissertation structures itself around three chapters with several subsections. The first chapter deals with the cultural history of the Quechua people. It presents the riches of their culture as also as the peculiarities of their religion, whose main expression and background is the Inti Raymi Festival. It describes the categories of Andean thought and the ways the Quechua organize their Cosmos (Pacha). The second one proposes a Christian theology that promotes the dialogue and the recognition of the presence of God’s revelation in all cultures and religions. The third one revolves around the dialogue-mission axis. Presents modes of mission among the Quechuas based on dialogue, understanding the evangelism as a give-and-receiving process. It understands enculturation as a formal dialogue with the religious foundations of the culture of the other.